American Indians and Alaskan Natives (AI/ANs) have some of the highest rates of substance use compared to other ethnic groups. The problem is particularly acute among Indian youth in reservations and remote rural areas and has been attributed to factors such as poverty, low cost and easy availability. The HAWK2 intervention is a multimedia, computer-based drug prevention program for Native youth in upper elementary and middle schools. The intervention uses engaging features such as games, animations, and video clips to impart substance abuse prevention knowledge and skills training. The development of this intervention was a collaborative process involving the participation of community experts, research scientists, school teachers and practitioners as well as Native youth. The intervention was sponsored by the National Institute of Drug Abuse. HAWK2 consists of seven lessons of 25-30 minutes each, with a total exposure time of 3.5 hours. Teachers have the flexibility to integrate the lessons into an existing health curriculum or to implement them as separate units over several weeks. Each session includes video segments that demonstrated refusal skills, conflict resolution, negotiation skills, coping skills, assertive communication, and relaxation techniques. Problem solving exercises allow participants to walk through different scenarios, identify problems, consider alternative responses, practice behavioral responses, and solve problems. Animations were used to convey Native American tales and legends that illustrate the positive impact of empowerment. Interactive quizzes, polls, and learning exercises were developed to reinforce prevention program content during and at the end of each lesson. The program is distributed on USB drive. A student (or a group of students) can view the program content on any computer and can self-administer the intervention. To run the program you will need computer with a USB drive and Speakers or Headphones (for privacy).